Prevention by tretinoin (all-trans-retinoic acid) of age-related renal changes.

  title={Prevention by tretinoin (all-trans-retinoic acid) of age-related renal changes.},
  author={Victoria Moreno-Manzano and Manuel Rodr{\'i}guez-Puyol and I Arribas-G{\'o}mez and Diego Rodr{\'i}guez-Puyol and Javier Lucio-Caza{\~n}a},
  journal={International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition},
  volume={67 6},
The present work shows that dietary tretinoin (all-trans-retinoic acid) supplementation may be a useful manoeuvre for the prevention of age-related renal changes. 18-month-old male Fischer 344 rats fed during three months with standard chow plus tretinoin (1 mg/kg/day) did not exhibit any adverse effect in terms of bodyweight, urinary volume, renal handling of sodium and both hematological and blood chemistry parameters. Although the diet did not reduce age-related proteinuria nor renal lipid… CONTINUE READING


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