• DOI:10.1016/0031-6989(86)90117-7
Corpus ID: 31235644

Prevention by thymidine against toxicity and glucose uptake inhibition of methotrexate on cultured Ehrlich ascites tumour cells.

@article{Fung1986PreventionBT,
  title={Prevention by thymidine against toxicity and glucose uptake inhibition of methotrexate on cultured Ehrlich ascites tumour cells.},
  author={K. P. Fung and S. Ng and W. Lam and Y. M. Choy},
  journal={Pharmacological research communications},
  year={1986},
  volume={18 8},
  pages={
          759-67
        }
}

K. P. Fung, S. Ng, +1 author Y. M. Choy

Published 1986

Biology, Medicine

Pharmacological research communications

Methotrexate (MTX) arrested cell growth and inhibited 2-deoxy-D-glucose uptake of Ehrlich ascites tumour cells in vitro. The changes of glucose concentrations in the culture media did not affect the degree of suppression of cell growth by MTX. Thymidine (dThd) protected against the toxic effect of MTX on the cells. It also prevented the inhibition effect on glucose uptake of the cells by MTX. MTX significantly suppressed the maximal uptake rate of glucose (Vmax) while addition of dThd… CONTINUE READING

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