Corpus ID: 40287228

Prevention by aluminium phosphate of gastric lesions induced by ethanol in the rat: role of endogenous prostaglandins and sulfhydryls.

@article{Duchteau1990PreventionBA,
  title={Prevention by aluminium phosphate of gastric lesions induced by ethanol in the rat: role of endogenous prostaglandins and sulfhydryls.},
  author={Armand Duch{\^a}teau and G{\'e}rard Thi{\'e}fin and S Varin-Bischoff and Edeltraut Garbe and Paul Zeitoun},
  journal={Histology and histopathology},
  year={1990},
  volume={5 1},
  pages={
          89-94
        }
}
This study was designed to demonstrate the cytoprotective effect of an antacid containing aluminium phosphate (Phosphalugel) against ethanol-induced gastric injury in the rat and to determine whether this cytoprotective effect is mediated by endogenous prostaglandins and sulfhydryls. We have quantitatively evaluated gastric mucosal lesions using macroscopic and histological techniques one hour after ethanol administration. Two ml of aluminium phosphate given orally one hour before… Expand
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References

SHOWING 1-10 OF 24 REFERENCES
Protection by metals against ethanol-induced gastric mucosal injury in the rat. Comparative biochemical and pharmacologic studies implicate protein sulfhydryls.
TLDR
Biochemical studies of endogenous SH showed that the protective metals and NEM decreased the glutathione concentration in the nonprotein fraction, whereas these metals diminished and N-ethylmaleimide, which antagonizes mucosal protection, elevated the cysteine concentrations in the protein fraction of the gastric mucosa. Expand
Prostaglandin cytoprotection against ethanol-induced gastric injury in the rat: A histologic and cytologic study
TLDR
Results indicate that prostaglandin does not prevent superficial surface mucus cell necrosis in ethanol-exposed mucosa even though it does spare cells in the pit base, and supports the hypothesis that the reepithelialization of the lamina propria is initiated by spared deep-lying pit cells. Expand
Prostaglandin protection of the gastric mucosa against alcohol injury--a dynamic time-related process. Role of the mucosal proliferative zone.
TLDR
The mucosal proliferative zone was severely damaged in controls within the first hour after ethanol administration, whereas 16,16-dimethyl prostaglandin E2 protected the zone from damage and prompt restoration of the surface epithelium and resumption of its barrier and transport functions. Expand
Gastric cytoprotection by antacids and papaverine in rats.
TLDR
Prostaglandin E2 (PGE2) prevented hemorrhagic ulceration of rat stomach mucosa induced by various procedures when given orally at a non-antisecretory dose, and a similar protective effect was seen after intragastric administration of papaverine. Expand
Gastric mucosal cytoprotection in the rat by cysteine
  • A. S. Salim
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1987
TLDR
The data suggest that cysteine maintains gastric mucin by a mechanism independent of acid secretion, and this protection was not associated with any significant effect on H+ output. Expand
Cytoprotection by Prostaglandins in Rats Prevention of Gastric Necrosis Produced by Alcohol, HCl, NaOH, Hypertonic NaCl, and Thermal Injury
TLDR
It is suggested that certain prostaglandins, by a mechanism other than the inhibition of gastric acid secretion, maintain the cellular integrity of the gastric mucosa, and might be beneficial in the treatment of a variety of diseases in which Gastric mucosal injury is present. Expand
Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin.
The striking reduction or absence of macroscopic necrotic lesions in rat stomachs exposed to necrotizing agents after treatment with prostaglandins has been described as "cytoprotection." However,Expand
Nonprotein sulfhydryl compounds in canine gastric mucosa: effects of PGE2 and ethanol.
TLDR
Findings are consistent with the hypothesis that nonprotein sulfhydryls may play a role in mediating gastric mucosal protection and show that exogenously administered prostaglandins and mild irritants can prevent gastrics mucosal damage by necrotizing agents. Expand
Ethanol-induced damage to mucosal capillaries of rat stomach. Ultrastructural features and effects of prostaglandin F2 beta and cysteamine.
TLDR
It is concluded that a 1-min exposure to 100% ethanol induces striking damage to the microcirculation of glandular mucosa of the rat stomach with severe damage to capillary profiles near the lumen and sparing of capillary profile near the muscularis mucosa, and pretreatment with the sulfhydryl agent, cysteamine, or with a large dose of prostaglandin F2 beta reduces the extent of but does not abolish ethanol-induced damage. Expand
Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: effect of prostaglandin cytoprotection.
TLDR
Alcohol-induced stasis of flow in injured areas may be of pathogenetic significance and prostaglandin protection might involve prevention of this microcirculatory change. Expand
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