Prevention and treatment strategies for glucocorticoid-induced osteoporotic fractures

  title={Prevention and treatment strategies for glucocorticoid-induced osteoporotic fractures},
  author={M. Gourlay and N. Franceschini and Yevgeniy Sheyn},
  journal={Clinical Rheumatology},
  • M. Gourlay, N. Franceschini, Yevgeniy Sheyn
  • Published 2006
  • Medicine
  • Clinical Rheumatology
  • Glucocorticoids are the most common cause of drug-related osteoporosis. We reviewed current evidence on risk factors for glucocorticoid-induced osteoporosis (GIOP) and prevention and treatment of GIOP-related fractures. Guidelines for GIOP management published since 2000 were also reviewed. Significant bone loss and increased fracture risk is seen with daily prednisone doses as low as 5 mg. Alternate-day glucocorticoid therapy can lead to similar bone loss. No conclusive evidence exists for a… CONTINUE READING
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