Prevention and treatment options for mTOR inhibitor-associated stomatitis

@article{Staves2017PreventionAT,
  title={Prevention and treatment options for mTOR inhibitor-associated stomatitis},
  author={Kelly Staves and K. Ramchandran},
  journal={The Journal of community and supportive oncology},
  year={2017},
  volume={15},
  pages={74-81}
}
Mammalian target of rapamycin (mTOR), a serine–threonine protein kinase, operates in the phosphoinositide 3-kinase (PI3K)–protein kinase B (AKT)–mTOR signal transduction pathway regulating both normal and cancer cellular processes, including cell growth, proliferation, motility, survival, and protein and lipid synthesis.1 Genetic alterations affecting this pathway, including mutations in receptor tyrosine kinases PI3K and AKT, occur frequently in human cancers,2 supporting the rationale to… Expand
Everolimus-based combination therapies for HR+, HER2- metastatic breast cancer.
TLDR
Key data on everolimus-based combinations focusing on efficacy, safety, biomarkers, quality of life, and health economic outcomes are summarized in the context of the changing MBC treatment algorithm. Expand
Prevention of Stomatitis
TLDR
Recommendations are provided for oncology nurses to educate patients on prevention, early detection, monitoring, and management strategies to mitigate the incidence and severity of everolimus‐related stomatitis. Expand

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