Prevention and treatment of factor VIII inhibitors in murine hemophilia A.

Abstract

Inhibitory antibody formation is a major complication of factor VIII replacement therapy in patients with hemophilia A. To better understand the pathogenesis of this immunologic reaction, we evaluated the role of T-cell costimulatory signals for antifactor VIII antibody formation in a murine model of hemophilia A. Repeated intravenous injections of factor… (More)

6 Figures and Tables

Topics

  • Presentations referencing similar topics