Prevention and treatment of Wernicke-Korsakoff syndrome.

  title={Prevention and treatment of Wernicke-Korsakoff syndrome.},
  author={Christopher C. H. Cook},
  journal={Alcohol and alcoholism (Oxford, Oxfordshire). Supplement},
  volume={35 1},
  • C. Cook
  • Published 1 May 2000
  • Medicine
  • Alcohol and alcoholism (Oxford, Oxfordshire). Supplement
Wernicke's encephalopathy (WE) is both common and associated with high morbidity and mortality and yet there is evidence that appropriate and effective prophylaxis and treatment are often not given. Effective treatment and prophylaxis may only be achieved by use of parenteral vitamin supplements, since oral supplements are not absorbed in significant amounts. Although there are rare anaphylactoid reactions associated with the use of parenteral thiamine preparations, the risks and consequences… Expand
Wernicke-sjúkdómur meðal áfengissjúkra
It is crucial in suspected cases of Wernicke's encephalopathy to immediately administer high-dose intravenous thiamine and simultaneously treat magnesium deficiency and Alcoholics at risk of THE AUTHORS should on admission receive immediate prophylactic therapy with parenteralThiamine. Expand
Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management
The optimum dose of parenteral thiamine required for prophylaxis and treatment of Wernicke's encephalopathy and prevention of Korsakoff's syndrome associated with alcohol misuse is emphasised. Expand
Gayet-Wernicke Encephalopathy: An Unusual Complication of Vomiting
Two cases of non-alcohol related THE AUTHORS complicating vomiting caused by different etiologies are described and the diagnosis was suspected on clinical presentation and confirmed by brain MRI and effective response to parenteral administration of thiamine. Expand
[Wernicke's encephalopathy in chronic alcoholics].
It is crucial in suspected cases of THE AUTHORS to immediately administer high-dose intravenous thiamine and simultaneously treat magnesium deficiency, as delay of appropriate treatment can lead to death or Korsakoff's amnestic syndrome. Expand
[Wernicke encephalopathy: Guiding thiamine prescription].
The literature does indicate that thiamine should be prescribed at high dosages, with the parenteral routes indicated in hospital settings and in high-risk patients. Expand
Wernicke-Korsakoff syndrome (WKS) in Australia: no room for complacency.
Australia has made a substantial contribution to the recognition and treatment of the Wernicke-Korsakoff syndrome, but it is not known how widespread these recommendations have been applied in Australia. Expand
Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol.
Evidence from randomised controlled clinical trials is insufficient to guide clinicians in determining the dose, frequency, route or duration of thiamine treatment for prophylaxis against or treatment of WKS due to alcohol abuse. Expand
Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse.
There is insufficient evidence from randomized controlled clinical trials to guide clinicians in the dose, frequency, route or duration of thiamine treatment for prophylaxis against or treatment of WKS due to alcohol abuse. Expand
Myths and misconceptions of Wernicke's encephalopathy: what every emergency physician should know.
The history of Wernicke's encephalopathy is traced from the first description to the current understanding of the disease and includes many of the misconceptions, myths, and controversies that surround this disease. Expand
Alcohol Induced Neurocognitive Impairment (Wernicke - Korsakoff): A Hidden Syndrome
Educating clinicians, specially emergency physicians about evaluation and treatment of Wernicke-Korsakoff syndrome is as important as to educate people to eat well balanced, mixed diet containing thiamine rich food as most of these patients receive emergency treatment but are frequently unrecognized. Expand


Wernicke's encephalopathy.
It is recommended that all comatose or hypothermic patients, as well as those with more classic presentations of Wernicke's encephalopathy, be given parenteral thiamine before administration of glucose. Expand
Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy.
Clinicians must maintain a high index of suspicion in the "at risk" group of patients, particularly alcoholics, to make the diagnosis of the Wernicke-Korsakoff syndrome and Investigations of thiamine status may be helpful and if the diagnosis is suspected, parenteralThiamine should be given. Expand
B Vitamin deficiency and neuropsychiatric syndromes in alcohol misuse.
The role of B vitamins in the aetiology and treatment of neuropsychiatric syndromes associated with alcohol misuse, with particular emphasis on the Wernicke Korsakoff syndrome is considered. Expand
Brain lesions in alcoholics: A neuropathological study with clinical correlations
The study confirmed the existence of a generalized alcoholic brain atrophy in alcoholics and suggested that inactive Wernicke's encephalopathy is the main underlying lesion both in Korsakoff's psychosis and "alcoholic dementia" but that additional lesions are present in the latter group. Expand
Alcohol and the central nervous system.
Acute Wernicke-Korsakoff syndrome is an underdiagnosed cause of reversible coma in the alcoholic patient and can result in the iatrogenic syndrome of central pontine myelinolysis. Expand
Current concepts. Wernicke's encephalopathy.
Despite its description over a century ago, Wernicke's encephalopathy continues to be underrecognized in both alcoholic and nonalcoholic populations. Recent studies suggest that Wernicke's encephal...
Managing alcohol dependence.