Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin-10 and interleukin-4.

@article{Roon1996PreventionAR,
  title={Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin-10 and interleukin-4.},
  author={Jo{\"e}l AG van Roon and Joris Van Roy and Frits H. J. Gmelig-Meyling and Floris P. Lafeber and Johannes W J Bijlsma Bijlsma},
  journal={Arthritis and rheumatism},
  year={1996},
  volume={39 5},
  pages={829-35}
}
OBJECTIVE Inflammation-induced articular cartilage degradation is a major problem in rheumatoid arthritis (RA). Type 1 T cell activity (characterized by interferon-gamma/interleukin-2 [IL-2] production), and consequently, the production of the proinflammatory cytokines IL-1 and tumor necrosis factor alpha (TNF alpha), have been reported to play a major role in cartilage damage. IL-10 and IL-4, both produced by type 2 T cells, are cytokines with the capacity to down-regulate proinflammatory… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

Similar Papers

Loading similar papers…