Prevention and management of asparaginase/pegasparaginase-associated toxicities in adults and older adolescents: recommendations of an expert panel.

@article{Stock2011PreventionAM,
  title={Prevention and management of asparaginase/pegasparaginase-associated toxicities in adults and older adolescents: recommendations of an expert panel.},
  author={Wendy Stock and Dan Douer and Daniel J. Deangelo and M. Soledad Arellano and Anjali A Advani and Lloyd Earl Damon and Tibor J Kovacsovics and Mark L Litzow and Michael Rytting and Gautam Borthakur and Archie Bleyer},
  journal={Leukemia & lymphoma},
  year={2011},
  volume={52 12},
  pages={2237-53}
}
The rapidly increasing use of pegasparaginase (pegASNase) in adults, after a half century of use of asparaginase (ASNase) in children, has prompted a need for guidelines in the management and prevention of toxicities of asparagine depletion in adults. Accordingly, an initial set of recommendations are provided herein. Major advantages of pegASNase are its 2-3-week duration of action, in contrast to less than 3 days with native ASNase, and the flexibility of intravenous or intramuscular… CONTINUE READING
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