Prevention and management of bicalutamide-induced gynecomastia and breast pain: randomized endocrinologic and clinical studies with tamoxifen and anastrozole

@article{Saltzstein2005PreventionAM,
  title={Prevention and management of bicalutamide-induced gynecomastia and breast pain: randomized endocrinologic and clinical studies with tamoxifen and anastrozole},
  author={Daniel R. Saltzstein and Paul R. Sieber and Tom H. Morris and Juan Jos{\'e} Duque Gallo},
  journal={Prostate Cancer and Prostatic Diseases},
  year={2005},
  volume={8},
  pages={75-83}
}
A randomized, double-blind, placebo-controlled multicenter trial involving 107 men receiving bicalutamide (‘Casodex’) 150 mg/day therapy following radical therapy for prostate cancer assessed tamoxifen (‘Nolvadex’) 20 mg/day and anastrozole (‘Arimidex’) 1 mg/day for the prophylaxis and treatment of gynecomastia/breast pain. Tamoxifen, but not anastrozole, significantly reduced the incidence of gynecomastia/breast pain when used prophylactically and therapeutically. Serum testosterone levels… CONTINUE READING
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