Prevention and intervention trials for colorectal cancer.

  title={Prevention and intervention trials for colorectal cancer.},
  author={Masami Komiya and Gen Fujii and Mami Takahashi and Masaaki Iigo and Michihiro Mutoh},
  journal={Japanese journal of clinical oncology},
  volume={43 7},
There have been a number of candidates for chemopreventive agents from synthetic drugs and natural compounds suggested to prevent colorectal cancer. However, they have shown modest efficacy in humans. The reason for this could be partly explained by the use of inappropriate models in vitro and in vivo, and the limitation of chemoprevention trials. In Japan, there are no cancer chemopreventive medicines, and few cancer chemoprevention trials to date. In contrast, an increase in the prevalence of… CONTINUE READING
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