Prevention and elimination of bovine viral diarrhea virus infections in fetal fibroblast cells.

@article{Givens2004PreventionAE,
  title={Prevention and elimination of bovine viral diarrhea virus infections in fetal fibroblast cells.},
  author={M. Daniel Givens and David A. Stringfellow and Christine C. Dykstra and Kay P. Riddell and Patricia K. Galik and Eddie J Sullivan and James M. Robl and Poothapillai Kasinathan and Arvind Kumar and David W Boykin},
  journal={Antiviral research},
  year={2004},
  volume={64 2},
  pages={
          113-8
        }
}
Effect of treatment with a cationic antiviral compound on acute infection with bovine viral diarrhea virus.
  • B. Newcomer, M. Marley, +7 authors M. Givens
  • Biology, Medicine
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
  • 2013
TLDR
This pilot study indicates that DB772 temporarily prevented acute disease due to BVDV, but carries a significant concern of renal toxicity.
Selection and characterization of canine, swine and rabbit cell lines resistant to bovine viral diarrhea virus.
TLDR
Three cell lines resistant to bovine viral diarrhea virus (BVDV), a major contaminant of cell cultures, are reported, which may be useful for many virology purposes, with a very low risk of BVDV contamination.
Mutations induced in the NS5B gene of bovine viral diarrhea virus by antiviral treatment convey resistance to the compound.
TLDR
DB772 appears to act by binding to the specified domain but binding is disrupted or inhibited by the described mutation, and growth curves for the mutant isolates were not largely different from those of wild-type isolates when cultured in the absence of DB772.
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
TLDR
It is concluded that LZ37 interacts with the same binding site as BPIP or VP32947 at the top of the finger domain of the polymerase that is a "hot spot" for inhibition of pestivirus replication.
Antiviral Treatment of Calves Persistently Infected with Bovine Viral Diarrhoea Virus
TLDR
Results demonstrate that DB772 administration is safe and exhibits antiviral properties in PI calves while facilitating the rapid development of viral resistance to this novel therapeutic agent.
Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species.
TLDR
DB772 effectively inhibits all pestiviruses studied at concentrations >0.20μM, as cytotoxicity is not evident at these concentrations, this antiviral compound potentially represents an effective preventative or therapeutic for diverse pestIViruses.
Elimination of Non-cytopathic Bovine Viral Diarrhea Virus From the LFBK-αvβ6 Cell Line
TLDR
An aromatic cationic compound (DB772) is used to treat LFBK-αvβ6 cells with an approach that has been previously used to eliminate persistent BVDV from fetal fibroblast cell lines and results can be handled without the risk of cross-contaminating other cells lines or reagents.
Mycoplasma bovis co-infection with bovine viral diarrhea virus in bovine macrophages
TLDR
It was observed that a widely used cell line of bovine macrophages (Bomac cells) is in fact persistently infected with BVDV, and this cell model is very useful when studying viral co- Infections with bacteria and could also be used for multiple co-infections.
Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase
TLDR
CSFC-resistant BVDV proved to be cross-resistant to earlier reported pestivirus inhibitors (BPIP, AG110, LZ37, and BBP) that are known to target the same region of the RdRp, and indicates that this region is a “hot spot” for the inhibition of pestiv virus replication.
A Novel, Highly Selective Inhibitor of Pestivirus Replication That Targets the Viral RNA-Dependent RNA Polymerase
TLDR
BPIP did not inhibit the in vitro activity of recombinant BVDV RdRp, but did inhibit the activity of replication complexes (RCs).
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TLDR
The screening method identified compounds that exhibited inhibition of BVDV at nanomolar concentrations while exhibiting no cytotoxicity at 25 μM concentrations and require further investigation to determine their mechanism of action, in vivo activity, and specific activity against hepatitis C virus.
Role of bovine viral diarrhea virus biotype in the establishment of fetal infections.
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Data suggest that the contaminating NCP virus in the NADL-A stock was the ancestral NADL virus, which originally infected a bovine fetus and recombined to produce a cytopathic (CP) variant.
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The data indicate that noncytopathic BVDV isolates may more easily induce thrombocytopenia than do cy topathic isolates in immune-naive, immunocompetent calves.
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All strains of BVDV persisted and replicated in the embryo culture environment, but cleavage beyond the 4-cell stage, blastocyst development and hatching varied among cultures contaminated with different strains of virus.
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Evidence is provided of the infective nature of the contaminant BVDV-2 and of its potential to generate disease outbreaks when inoculated into susceptible animals when inoculating intranasally into four 3-month-old calves.
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TLDR
Treatment with long-alkyl-chain deoxynojirimycin derivatives, which are inhibitors of the endoplasmic reticulum (ER)-resident α-glucosidases, can greatly reduce the amount of secreted enveloped viral RNA.
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  • Biology, Medicine
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
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TLDR
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TLDR
Most commercially available bovine sera are contaminated with BVDV and, although there is no evidence that the virus is infectious, bovian sera should be screened for this virus by RT-PCR when used in conjunction with HCV or for the development or production of vaccine.
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    Revue scientifique et technique
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TLDR
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