Prevention and control of Chagas Disease : an overview

  title={Prevention and control of Chagas Disease : an overview},
  author={A. Teixeira and C. Gomes and A. Rosa and P. F. Ara{\'u}jo and C. Anunciaç{\~a}o and E. Silveira-Lacerda and Adriana B Almeida and S. Petrofeza},
Chagas disease is the main cause of heart failure and sudden death in the Western Hemisphere. The literature of the last decades reported on the changing epidemiological profiles of Chagas disease, which now threats the human population in the cities. The exodus of the Latin America people to the Northern Hemisphere explains the growing concern in countries where the transmission of Trypanosoma cruzi was accidental or transferred from a mother to her offspring. Herein, we present the… Expand
4 Citations
American trypanosomiasis and Chagas disease: Sexual transmission.
Investigation of the routes of transmission of Trypanosoma cruzi parasites and the distribution of Chagas disease found that the blood protozoan T. cruzi can be transmitted sexually from infected males and females to naïve mates has implications for public health. Expand
Blood transfusion and diagnostic accuracy of chagas disease
Chagas disease used to be limited to rural regions of the American Continent infested with triatomine (Reduviidae:Triatomine) bug transmitter of Trypanosoma cruzi infection, but is now present in five Continents and poses a growing burden to the public health systems. Expand
A Mechanistic Probe into the Dual Inhibition of T. cruzi Glucokinase and Hexokinase in Chagas Disease Treatment – A Stone Killing Two Birds?
Insight is provided into the underlying mechanisms of dual inhibition exhibited by the compounds and can pave way to discover and optimize novel dual Tc inhibitors with favorable pharmacokinetics properties eventuating in the mitigation of Chagas disease. Expand
Sesquiterpene lactone potentiates the immunomodulatory, antiparasitic and cardioprotective effects on anti-Trypanosoma cruzi specific chemotherapy.
The findings indicated that the combination of tagitinin C and Bz exerts potent antiparasitic, immunomodulatory and cardioprotective effects, indicating a high potential for the treatment of Chagas's disease. Expand


Globalization of Chagas Disease: A Growing Concern in Nonendemic Countries
Physicians in nonendemic countries should be able to recognize signs and symptoms of acute and chronic Chagas disease as migration and globalization increase the burden of disease in non-endemic areas. Expand
Chagas Disease Drug Discovery
  • E. Chatelain
  • Biology, Medicine
  • Journal of biomolecular screening
  • 2015
New developments in the Chagas field, including new technologies and tools now available, will be discussed, and a redesign of the current screening strategy during the discovery process is proposed. Expand
Chagas Disease in Non-Endemic Countries: Epidemiology, Clinical Presentation and Treatment
Imported Chagas disease (Trypanosoma cruzi infection) is increasingly recognized as an emerging problem in the USA and Europe due to immigration from Latin America and many countries are currently facing the challenge of this emerging public health problem. Expand
Chagas' Disease: Pregnancy and Congenital Transmission
To control transmission, it is essential to test all pregnantWomen living in endemic countries and all pregnant women having migrated from, or having lived in, endemic countries for Chagas disease. Expand
Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps.
Emergent diagnostic tests integrating these novel and tailored tools should provide a significant impact on the effectiveness of current intervention schemes and on the clinical management of Chagasic patients. Expand
Oral transmission of Chagas disease.
Oral transmission of Chagas disease is considered when >1 acute case of febrile disease without other causes is linked to a suspected food and should be confirmed by the presence of the parasite after direct microscopic examination of the blood or other biological fluid sample from the patient. Expand
Chagas disease
The pathogenesis of Chagas disease appears to be related to a parasite-induced mutation of the vertebrate genome, and treatment is unsatisfactory. Expand
Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity
The phenotyping of the lesions revealed that cytotoxic CD45, CD8+ γδ, and CD8α+ T lymphocytes carry out the rejection of the chicken heart, suggesting that the inflammatory cardiomyopathy of Chagas' disease is a genetically driven autoimmune disease. Expand
Trypanosoma cruzi and Chagas' Disease in the United States
The United States can play an important role in addressing the altered epidemiology of Chagas' disease in the 21st century as improved control of vector- and blood-borne T. cruzi transmission decreases the burden in countries where the disease is historically endemic. Expand
Trypanosoma cruzi in the Chicken Model: Chagas-Like Heart Disease in the Absence of Parasitism
It is suggested that genetic alterations resulting from kDNA integration in the host genome lead to autoimmune-mediated destruction of heart tissue in the absence of T. cruzi parasites. Expand