Prevention and control of Chagas Disease : an overview

@inproceedings{Teixeira2018PreventionAC,
  title={Prevention and control of Chagas Disease : an overview},
  author={A. Teixeira and C. Gomes and A. Rosa and P. F. Ara{\'u}jo and C. Anunciaç{\~a}o and E. Silveira-Lacerda and Adriana B Almeida and S. Petrofeza},
  year={2018}
}
Chagas disease is the main cause of heart failure and sudden death in the Western Hemisphere. The literature of the last decades reported on the changing epidemiological profiles of Chagas disease, which now threats the human population in the cities. The exodus of the Latin America people to the Northern Hemisphere explains the growing concern in countries where the transmission of Trypanosoma cruzi was accidental or transferred from a mother to her offspring. Herein, we present the… Expand
4 Citations
American trypanosomiasis and Chagas disease: Sexual transmission.
TLDR
Investigation of the routes of transmission of Trypanosoma cruzi parasites and the distribution of Chagas disease found that the blood protozoan T. cruzi can be transmitted sexually from infected males and females to naïve mates has implications for public health. Expand
Blood transfusion and diagnostic accuracy of chagas disease
TLDR
Chagas disease used to be limited to rural regions of the American Continent infested with triatomine (Reduviidae:Triatomine) bug transmitter of Trypanosoma cruzi infection, but is now present in five Continents and poses a growing burden to the public health systems. Expand
A Mechanistic Probe into the Dual Inhibition of T. cruzi Glucokinase and Hexokinase in Chagas Disease Treatment – A Stone Killing Two Birds?
TLDR
Insight is provided into the underlying mechanisms of dual inhibition exhibited by the compounds and can pave way to discover and optimize novel dual Tc inhibitors with favorable pharmacokinetics properties eventuating in the mitigation of Chagas disease. Expand
Sesquiterpene lactone potentiates the immunomodulatory, antiparasitic and cardioprotective effects on anti-Trypanosoma cruzi specific chemotherapy.
TLDR
The findings indicated that the combination of tagitinin C and Bz exerts potent antiparasitic, immunomodulatory and cardioprotective effects, indicating a high potential for the treatment of Chagas's disease. Expand

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