Preventing ventricular fibrillation by flattening cardiac restitution.

  title={Preventing ventricular fibrillation by flattening cardiac restitution.},
  author={Alan Garfinkel and Yun Hyeon Kim and Olga Voroshilovsky and Zhilin Qu and John Kil and Min Ho Lee and Hrayr S. Karagueuzian and James N. Weiss and P S Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 11},
Ventricular fibrillation is the leading cause of sudden cardiac death. In fibrillation, fragmented electrical waves meander erratically through the heart muscle, creating disordered and ineffective contraction. Theoretical and computer studies, as well as recent experimental evidence, have suggested that fibrillation is created and sustained by the property of restitution of the cardiac action potential duration (that is, its dependence on the previous diastolic interval). The restitution… CONTINUE READING


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