Preventing transcriptional gene silencing by active DNA demethylation.

  title={Preventing transcriptional gene silencing by active DNA demethylation.},
  author={Avnish Kapoor and Fernanda Agius and Jian-Kang Zhu},
  journal={FEBS letters},
  volume={579 26},
DNA methylation is important for stable transcriptional gene silencing. DNA methyltransferases for de novo as well as maintenance methylation have been well characterized. However, enzymes responsible for active DNA demethylation have been elusive and several reported mechanisms of active demethylation have been controversial. There has been a critical need for genetic analysis in order to firmly establish an in vivo role for putative DNA demethylases. Mutations in the bifunctional DNA… CONTINUE READING