Preventing the Interaction between Coronaviruses Spike Protein and Angiotensin I Converting Enzyme 2: An In Silico Mechanistic Case Study on Emodin as a Potential Model Compound

  title={Preventing the Interaction between Coronaviruses Spike Protein and Angiotensin I Converting Enzyme 2: An In Silico Mechanistic Case Study on Emodin as a Potential Model Compound},
  author={Luca Dellafiora and Jean-Lou C. M. Dorne and Gianni Galaverna and Chiara Dall’Asta},
  journal={Applied Sciences},
Emodin, a widespread natural anthraquinone, has many biological activities including health-protective and adverse effects Amongst beneficial effects, potential antiviral activity against coronavirus responsible for the severe acute respiratory syndrome outbreak in 2002–2003 has been described associated with the inhibition of the host cells target receptors recognition by the viral Spike protein However, the inhibition mechanisms have not been fully characterized, hindering the rational use of… 

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