Preventing misidentification of 25I-NBOH as 2C-I on routine GC–MS analyses

  title={Preventing misidentification of 25I-NBOH as 2C-I on routine GC–MS analyses},
  author={Jos{\'e} Coelho Neto and Ana Fl{\'a}via B Andrade and Rog{\'e}rio Ara{\'u}jo Lordeiro and Yuri Machado and Mathieu P Elie and Ettore Ferrari J{\'u}nior and Luciano Chaves Arantes},
  journal={Forensic Toxicology},
Abstract25I-NBOH is a novel psychoactive substance (NPS) recently reported to have been found on blotter paper samples seized on the streets of Brazil, and used as a replacement for the NBOMes now scheduled in many countries. The presence of this NPS on the street market may go undetected, because the most widely and routinely utilised analytical technique for drug sample analyses is gas chromatography–mass spectrometry (GC–MS), which can misidentify 25I-NBOH (and indeed the other members of… 
Identification of new NBOH drugs in seized blotter papers: 25B-NBOH, 25C-NBOH, and 25E-NBOH
Purpose The recreational drug market remains dynamic. After the introduction of 25I-NBOH, an N -benzylphenethylamine and new psychoactive substance, as option for LSD and NBOMe drugs, new NBOH
Electroanalytical identification of 25I-NBOH and 2C-I via differential pulse voltammetry: a rapid and sensitive screening method to avoid misidentification.
A novel, fast and sensitive electrochemical method for the detection of 25I-NBOH using a SPCE is described and all method characteristics demonstrated the method to be analytically valuable.
NBOMe Designer Drugs: GC-MS and LC-QTOF/MS Detection on Blotter Paper by Brazilian Federal Police (Rio Grande do Sul, Brazil)
For research and drug intelligence purposes the use of more versatile, sensitive and specific analytical tool provides a greater number of information that could be employed as a valuable strategy in the drug trafficking combat.


25I-NBOH: a new potent serotonin 5-HT2A receptor agonist identified in blotter paper seizures in Brazil
The 25I-NBOH is a labile molecule, which fragments into 2C-I when analyzed by routine seized material screening gas chromatography methods, and GC–mass spectrometry, liquid chromatography–quadrupole time-of-flight-MS, and Fourier transform infrared and nuclear magnetic resonance analyses were performed to complete molecular characterization.
NBOMe — a very different kettle of fish …
It is concerned that recent media reports about a 17-year-old Sydney boy who died after allegedly consuming 25Bor 25I-NBOMe might lead to an increase in the incidence of NBOMe toxicity among patients presenting to emergency departments.
Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice
The effectiveness with which M100907 antagonized the behavioral actions of 25CN-NBOH strongly suggests that the 5-HT2A receptor is an important site of agonist action for this compound in vivo.
Molecular Interaction of Serotonin 5-HT2A Receptor Residues Phe339(6.51) and Phe340(6.52) with Superpotent N-Benzyl Phenethylamine Agonists
This study is the first to identify a hitherto unrecognized role for residue 6.51 in agonist activation of a serotonin G protein-coupled receptor (GPCR), whereas most previous reports have suggested a varied and sometimes contradictory role in homologous GPCRs.