Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors

@inproceedings{Holland2015PreventingFO,
  title={Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors},
  author={Andrew J Holland and Rita M Reis and Sherry M Niessen and Cl{\'a}udia Pereira and Douglas A. Andres and Hans Peter Spielmann and Don W Cleveland and Arshad Desai and Reto Gassmann},
  booktitle={Molecular biology of the cell},
  year={2015}
}
The clinical interest in farnesyltransferase inhibitors (FTIs) makes it important to understand how these compounds affect cellular processes involving farnesylated proteins. Mitotic abnormalities observed after treatment with FTIs have so far been attributed to defects in the farnesylation of the outer kinetochore proteins CENP-E and CENP-F, which are involved in chromosome congression and spindle assembly checkpoint signaling. Here we identify the cytoplasmic dynein adaptor Spindly as an… CONTINUE READING