Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking.

@article{Ge2012PreventingBD,
  title={Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking.},
  author={Jianning Ge and Yi-Nan Gong and Ying Bo Xu and Feng Shao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 16},
  pages={6193-8}
}
Legionella pneumophila, the causative agent of Legionnaires' pneumonia, resides in a distinct vacuole structure called Legionella-containing vacuole (LCV). The LCV resists fusion with the lysosome and permits efficient bacterial replication in host macrophages, which requires a Dot/Icm type IVB secretion system. Dot/Icm-translocated effector SdhA is critical for L. pneumophila intracellular growth and functions to prevent host cell death. Here, we show that the absence of SdhA resulted in… CONTINUE READING
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