Preventing Dangerous Nonsense: Selection for Robustness to Transcriptional Error in Human Genes

Abstract

Nonsense Mediated Decay (NMD) degrades transcripts that contain a premature STOP codon resulting from mistranscription or missplicing. However NMD's surveillance of gene expression varies in efficiency both among and within human genes. Previous work has shown that the intron content of human genes is influenced by missplicing events invisible to NMD. Given… (More)
DOI: 10.1371/journal.pgen.1002276

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@inproceedings{Cusack2011PreventingDN, title={Preventing Dangerous Nonsense: Selection for Robustness to Transcriptional Error in Human Genes}, author={Brian P. Cusack and Peter F. Arndt and Laurent Duret and Hugues Roest Crollius}, booktitle={PLoS genetics}, year={2011} }