Preventing Allograft Rejection by Targeting Immune Metabolism.

  title={Preventing Allograft Rejection by Targeting Immune Metabolism.},
  author={Chen-Fang Lee and Y Lo and Chih-Hsien Cheng and Georg J. Furtm{\"u}ller and Byoungchol Oh and Vin{\'i}cius Andrade-Oliveira and Ajit G. Thomas and Caitlyn Bowman and Barbara S Slusher and Michael J Wolfgang and Gerald Brandacher and Jonathan D. Powell},
  journal={Cell reports},
  volume={13 4},
Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells regulates T cell activation and differentiation but is not just a consequence of antigen recognition. Although such metabolic reprogramming promotes the differentiation… CONTINUE READING