Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation

  title={Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation},
  author={Eun Jung Kim and Geza Erdos and Shaohua Huang and Thomas W. Kenniston and Louis D. Falo and Andrea A. Gambotto},
Since it emerged in Brazil in May 2015, the mosquito-borne Zika virus (ZIKV) has raised global concern due to its association with a significant rise in the number of infants born with microcephaly and neurological disorders such as Guillain-Barré syndrome. We developed prototype subunit and adenoviral-based Zika vaccines encoding the extracellular portion of the ZIKV envelope gene (E) fused to the T4 fibritin foldon trimerization domain (Efl). The subunit vaccine was delivered intradermally… CONTINUE READING
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