Prevalidation study of the BALB/c 3T3 cell transformation assay for assessment of carcinogenic potential of chemicals.

@article{Tanaka2012PrevalidationSO,
  title={Prevalidation study of the BALB/c 3T3 cell transformation assay for assessment of carcinogenic potential of chemicals.},
  author={Noriho Tanaka and Susanne Bohnenberger and Thorsten Kunkelmann and Barbara Munaro and Jacopo M. De Ponti and Albrecht Poth and Enrico Sabbioni and Ayako Sakai and Susan Salovaara and Kiyoshi Sasaki and Brittany C Thomas and Makoto Umeda},
  journal={Mutation research},
  year={2012},
  volume={744 1},
  pages={
          20-9
        }
}
The cell transformation assays (CTAs) have attracted attention within the field of alternative methods due to their potential to reduce the number of animal experiments in the field of carcinogenicity. The CTA using BALB/c 3T3 cells has proved to be able to respond to chemical carcinogens by inducing morphologically transformed foci. Although a considerable amount of data on the performance of the assay has been collected, a formal evaluation focusing particularly on reproducibility, and a… CONTINUE READING
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