Prevalidation of in vitro continuous flow exposure systems as alternatives to in vivo inhalation safety evaluation experimentations: outcome from MAAPHRI-PCRD5 research program.

@article{Morin2008PrevalidationOI,
  title={Prevalidation of in vitro continuous flow exposure systems as alternatives to in vivo inhalation safety evaluation experimentations: outcome from MAAPHRI-PCRD5 research program.},
  author={Jean-Paul Morin and Virginie Hasson and Mamadou Fall and Eleni Papaioanou and David Pr{\'e}terre and Frantz Gouriou and Veronika Keravec and A. G. Konstandopoulos and Fr{\'e}d{\'e}ric Dionnet},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={2008},
  volume={60 2-3},
  pages={
          195-205
        }
}
Diesel engine emission aerosol-induced toxicity patterns were compared using both in vitro (organotypic cultures of lung tissue) and in vivo experimentations mimicking the inhalation situation with continuous aerosol flow exposure designs. Using liquid media resuspended diesel particles, we show that toxic response pattern is influenced by the presence of tensioactive agent in the medium which alter particle-borne pollutant bioavailability. Using continuous aerosol exposure in vitro, we show… CONTINUE READING

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Precision cut lung slices as an efficient tool for in vitro lung physio-pharmacotoxicology studies.

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