Prevalent positive epistasis in E. coli and S. cerevisiae metabolic networks

@inproceedings{He2010PrevalentPE,
  title={Prevalent positive epistasis in E. coli and S. cerevisiae metabolic networks},
  author={Xionglei He and Wenfeng Qian and Zhi Wang and Ying Li and Jianzhi Zhang},
  booktitle={Nature Genetics},
  year={2010}
}
Epistasis refers to the interaction between genes. Although high-throughput epistasis data from model organisms are being generated and used to construct genetic networks, the extent to which genetic epistasis reflects biologically meaningful interactions remains unclear. We have addressed this question through in silico mapping of positive and negative… CONTINUE READING