Prevalent overexpression of prolyl isomerase Pin1 in human cancers.

  title={Prevalent overexpression of prolyl isomerase Pin1 in human cancers.},
  author={Lere Bao and Amy Kimzey and Guido Sauter and Janusz M. Sowadski and Kun Lu and Da-Gong Wang},
  journal={The American journal of pathology},
  volume={164 5},
Phosphorylation of proteins on serine or threonine residues preceding proline (pSer/Thr-Pro) is a major regulatory mechanism in cell proliferation and transformation. Interestingly, the pSer/Thr-Pro motifs in proteins exist in two distinct cis and trans conformations, whose conversion rate is normally reduced on phosphorylation, but is catalyzed specifically by the prolyl isomerase Pin1. Pin1 can catalytically induce conformational changes in proteins after phosphorylation, thereby having… CONTINUE READING