Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance

  title={Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance},
  author={Kelley R. Healey and Yanan Zhao and Winder B. Perez and Shawn R. Lockhart and Jack D. Sobel and Dimitrios Farmakiotis and Dimitrios P Kontoyiannis and Dominique Sanglard and Saad J Taj-Aldeen and Barbara Dudley Alexander and Cristina Jim{\'e}nez-Ortigosa and Erika Shor and David Scott Perlin},
  booktitle={Nature communications},
The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles and/or echinocandins. Thus far, cellular mechanisms promoting the emergence of resistance to multiple drug classes have not been described in this organism. Here we demonstrate that a mutator phenotype caused by a mismatch repair defect is prevalent in C. glabrata clinical isolates. Strains carrying alterations in mismatch repair gene MSH2… CONTINUE READING
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MIC values, echinocandin resistance, and multidrug resistance

  • Pham, C. D. et al. Role of FKS mutations in Candida glabrata
  • Antimicrob. Agents Chemother. 58, 4690–4696
  • 2014

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