Prevalencia de hiperandrogenismo y síndrome de ovario poliquístico en transexuales de mujer a hombre

  title={Prevalencia de hiperandrogenismo y s{\'i}ndrome de ovario poliqu{\'i}stico en transexuales de mujer a hombre},
  author={Antonio Becerra-Fern{\'a}ndez and Gilberto P{\'e}rez-L{\'o}pez and Miriam Menacho Rom{\'a}n and Juan F. Mart{\'i}n-Lazaro and Mar{\'i}a Jes{\'u}s Mediavilla P{\'e}rez and Nuria Asenjo Araque and Jos{\'e} Miguel Rodr{\'i}guez-Molina and Mª del Carmen Berrocal Sertucha and M.ª V. Aguilar Vilas},
  journal={Endocrinolog{\'i}a y Nutrici{\'o}n},

Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals

5 Central genes were identified in PCOS and transsexuals and may cause the ubiquitination of androgen receptor and eventually lead to sinus follicular growth arrest and can be used as targets for early diagnosis or treatment of PCOS.

Functional ovarian reserve in transgender men receiving testosterone therapy: evidence for preserved anti-Müllerian hormone and antral follicle count under prolonged treatment.

Serum anti-Müllerian Hormone levels slightly decrease during testosterone treatment but remain within the normal range, suggesting preserved follicular ovarian reserve, an additional contribution to the emerging evidence that prolonged testosterone treatment may not be a major obstacle to later fertility potential in transgender men desirous of having children.

Non-HIV chronic disease burden among transgender populations globally: A systematic review and narrative synthesis

Androgen supplementation in assisted reproduction: where are we in 2019?

Although testosterone supplementation may be beneficial in POR, published studies have used inconsistent doses and duration of administration, and it is worrisome that androgens are used off-label, despite that the available evidence is weak.

Role of androgens in the ovary

A mouse model to investigate the impact of testosterone therapy on reproduction in transgender men.

This report describes the first mouse model mimicking T therapy given to transgender men that facilitates analysis of reproductive changes and supports a role for T therapy in suppressing the hypothalamic-pituitary-gonadal axis in adult female mice.

Role of androgens in normal and pathological ovarian function.

Androgens mediate their actions via the androgen receptor (AR), a member of the nuclear receptor superfamily. AR-mediated androgen action is essential in male reproductive development and function;

Transcripts Encoding the Androgen Receptor and IGF-Related Molecules Are Differently Expressed in Human Granulosa Cells From Primordial and Primary Follicles

The study hints the possibility that primordial follicles may indeed be androgen responsive, and that the action of androgens represents a connection to the expression of key players in the IGF-signaling pathway including IGF1R, IGF2, and IGFBP3, and this interaction could be important for early follicular activation.



Association between polycystic ovary syndrome and female-to-male transsexuality.

FTM transsexual patients have a high prevalence of PCOS and hyperandrogenaemia, and insulin resistance was associated with obesity but not with PCOS, in contrast, hyperandregenaemia wasassociated with bothPCOS and obesity.

Prevalence of polycystic ovary syndrome and hyperandrogenemia in female-to-male transsexuals.

Investigation of the prevalence of PCOS and hyperandrogenemia in female-to-male transsexuals (FMTs) found that FMTs more frequently had biochemicalhyperandrogenism, but there was a significantly higher prevalence of biochemical hyper androgenism in F MTs.

Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study.

In a consecutive population of unselected women the prevalence of hirsutism varied from 2-8% depending on the chosen cut-off F-G score, with no significant difference between White and Black women.

The prevalence and features of the polycystic ovary syndrome in an unselected population.

Data from a large representative unselected population support the concept that PCOS is the most common endocrine abnormality of reproductive-aged women in the United States.

Evidence for Association Between Polycystic Ovary Syndrome and Premature Carotid Atherosclerosis in Middle-Aged Women

It is suggested that lifelong exposure to an adverse cardiovascular risk profile in women with PCOS may lead to premature atherosclerosis, and the PCOS-IMT association is explained in part by weight and fat distribution and associated risk factors.

Transsexualism in Serbia: a twenty-year follow-up study.

Although transsexualism is a universal phenomenon, the relatively young age of those applying for sex reassignment and the sex ratio of 1:1 distinguish the population in Serbia from others reported in the literature.

Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome.

PCOS is associated with enhanced androgen and cortisol metabolite excretion and increased 5 alpha-reductase activity that cannot be explained by obesity alone.