Prevalence of use and acute toxicity associated with the use of NBOMe drugs

@article{Wood2015PrevalenceOU,
  title={Prevalence of use and acute toxicity associated with the use of NBOMe drugs},
  author={David M. Wood and Roumen Sedefov and Andrew Cunningham and Paul I. Dargan},
  journal={Clinical Toxicology},
  year={2015},
  volume={53},
  pages={85 - 92}
}
Abstract Introduction. The 25X-NBOMe series are N-2-methoxybenzyl analogues of the respective 2C-X substituted phenethylamine and include 25B-N(BOMe)2, 25B-NBOMe, 25C-NBOMe, 25D-NBOMe, 25E-NBOMe, 25G-NBOMe, 25H-NBOMe, 25I-NBOMe, 25N-NBOMe and 25iP-NBOMe. There are reports of their use as novel psychoactive substances and associated acute toxicity from Europe, the United States and elsewhere over the last five years. This review will discuss the epidemiology of use and pattern of acute toxicity… 

Case series: toxicity from 25B-NBOMe – a cluster of N-bomb cases

It is suggested that management should be supportive and focused on preventing further (self) harm from 25B-NBOMe, and high doses of benzodiazepines may be required to control agitation.

NBOMes–Highly Potent and Toxic Alternatives of LSD

An updated overview of the pharmacological properties, pattern of use, metabolism, and desired effects associated with NBOMe use is provided and the analytical methods most commonly used for detection and identification of NBOMes and their metabolites are presented.

Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH.

The major CYP enzymes involved in the metabolism of 25I-NBOMe and 25INBOH were identified as CYP3A4 and CYP2D6, respectively.

Recommendations for specimen collection for NBOMe analysis in clinical toxicology

Parents NBOMe may be a reliable urine biomarker, particularly in scenarios following recent drug use as in ED toxicological testing, as well as postmortem fluid and tissue specimens from Medical Examiners’ cases across the United States and around the world.

25C-NBOMe, a Novel Designer Psychedelic, Induces Neurotoxicity 50 Times More Potent Than Methamphetamine In Vitro

It is found that 25C-NBOMe potently reduced cell viability of SH-SY5Y, PC12, and SN4741 cells, with IC50 values of 89, 78, and 62 μM, respectively, and that the inhibition of the Akt pathway and activation of the ERK cascade might be involved in25C- NBOMe-induced neurotoxicity.

NBOMe and 2C substitute phenylethylamine exposures reported to the National Poison Data System

Common clinical effects of NBOMe and 2C exposures were tachycardia, agitation/irritable, hallucination/delusion, confusion, and hypertension.

Beware of blotting paper hallucinogens: severe toxicity with NBOMes

25B-NBOMe is consistent with previous reports of severe NBOMe toxicity, with agitation, tachycardia and mild hypertension, seizures, rhabdomyolysis and acute kidney injury.
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