Prevalence of thrombocytopenia among patients with chronic hepatitis C: a systematic review

@article{Louie2011PrevalenceOT,
  title={Prevalence of thrombocytopenia among patients with chronic hepatitis C: a systematic review},
  author={K S Louie and Joanne M Micallef and Jeanne M Pimenta and Ulla M. Forss{\'e}n},
  journal={Journal of Viral Hepatitis},
  year={2011},
  volume={18}
}
Summary.  Thrombocytopenia (TCP) is a haematological condition known to occur in chronically infected hepatitis C (HCV) patients and may interfere with diagnostic procedures, such as liver biopsy, because of risk of bleeding. It may also exclude patients from effective antiviral treatment. We conducted a systematic literature review of articles and conference abstracts, to assess the prevalence of TCP among those with HCV and to describe demographics, liver disease stage and treatment… 

Epidemiology of thrombocytopenia in patients with chronic hepatitis C: more than meets the eye

TLDR
The results of this epidemiological review provide an indirect evidence that confirms the multiplicity of aetiological factors underlying the pathophysiology of thrombocytopenia in chronic hepatitis C patients and shows that up to 25% of patients treated with interferon may develop some degree of thROMbocytopsia, and this may be associated with decreased sustained virological response rates.

FREQUENCY OF THROMBOCYTOPENIA ; PATIENTS WITH CHRONIC HEPATITIS C INFECTION

TLDR
The frequency of thrombocytopenia in patients with Chronic Hepatitis C infection was found to be higher and patients of age more than 60 years and of child-Pugh class C affected the most.

Chronic hepatitis C-associated thrombocytopenia: aetiology and management.

  • Y. Fouad
  • Medicine, Biology
    Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • 2013
TLDR
The ability to increase platelet levels could significantly reduce the need for platelet transfusions and facilitate the use of interferon-based antiviral therapy and other medically indicated treatments in patients with liver disease.

FREQUENCY OF THROMBOCYTOPENIA;

TLDR
The frequency of thrombocytopenia in patients with Chronic Hepatitis C infection was found to be higher and patients of age more than 60 years and of child-Pugh class C affected the most.

Thrombocytopenia in Patients with Chronic Hepatitis C Virus Infection

TLDR
Thrombocytopenia in chronic HCV infection remain a major problem, however the recent change in DAAs without IFN, as the frontline therapy for HCV, permit to avoid the dilemmas associated with initiating or maintaining IFN based anti-viral therapy.

Effect of Direct-Acting Antiviral Therapy on Thrombocytopenic Patients with Hepatitis C Virus-Related Chronic Liver Disease

TLDR
Sofosbuvir-based DAA therapy is a highly effective and safe treatment regimen that results in the improvement of platelet count in thrombocytopenic patients, particularly in mild to moderate stages of hepatic fibrosis.

Reasons for nonuse of antiviral treatment in patients with chronic hepatitis C infection and thrombocytopaenia: a retrospective chart review from five European countries

TLDR
Thrombocytopaenia is one of many factors, indicative of the poor clinical state of the patient, that contributes to withholding antiviral treatment and can be considered as a modifiable factor to enable more HCV patients to receive guideline‐recommended therapy and thus improved clinical outcomes.

Effect of splenectomy on platelets associated antibodies in hepatitis C patients with thrombocytopenia

TLDR
Autoimmune mechanism plays an important role in the HCV-associated thrombocytopenia and spleen is a major source of PAIgs in patients with chronic HCV infection presplenectomy.

Trends in the prevalence of thrombocytopenia among individuals iInfected with hepatitis C Virus in the United States, 1999-2008

TLDR
As the HCV-infected population ages, the prevalence of thrombocytopenia is expected to rise, and this study provides limited evidence of such an effect at the national level.
...

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