Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters.

@article{Yang2007PrevalenceOT,
  title={Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters.},
  author={Chuhu Yang and Eugene Bolotin and Tao Jiang and Frances M. Sladek and Ernest Martinez},
  journal={Gene},
  year={2007},
  volume={389 1},
  pages={52-65}
}
The core promoter of eukaryotic genes is the minimal DNA region that recruits the basal transcription machinery to direct efficient and accurate transcription initiation. The fraction of human and yeast genes that contain specific core promoter elements such as the TATA box and the initiator (INR) remains unclear and core promoter motifs specific for TATA-less genes remain to be identified. Here, we present genome-scale computational analyses indicating that approximately 76% of human core… CONTINUE READING
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