Prevalence of the hepatitis C virus NS3 polymorphism Q80K in genotype 1 patients in the European region.

@article{Sarrazin2015PrevalenceOT,
  title={Prevalence of the hepatitis C virus NS3 polymorphism Q80K in genotype 1 patients in the European region.},
  author={Christoph Sarrazin and Erkki Lathouwers and Monika Peeters and Bjorn Daems and Annemie Buelens and James Witek and Yves Wyckmans and B. Fevery and Thierry Verbinnen and Anne Ghys and Michael Schlag and Alessandra Baldini and Sandra M J De Meyer and Oliver Lenz},
  journal={Antiviral research},
  year={2015},
  volume={116},
  pages={10-6}
}
Hepatitis C virus (HCV) NS3 polymorphism Q80K is mainly found in patients with HCV genotype (G) 1a, and has been associated with a reduced treatment response to simeprevir with pegylated interferon (P) and ribavirin (R). Prevalence of Q80K among G1 patients may vary geographically. Q80K prevalence in the North-American G1 population in a recent study was 34%. We conducted a post hoc meta-analysis of Q80K polymorphism prevalence among HCV G1-infected patients enrolled in simeprevir and… CONTINUE READING
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