Prevalence of the factor V-Leiden mutation in four distinct American ethnic populations.

@article{Gregg1997PrevalenceOT,
  title={Prevalence of the factor V-Leiden mutation in four distinct American ethnic populations.},
  author={J P Gregg and Akio Yamane and Wayne W. Grody},
  journal={American journal of medical genetics},
  year={1997},
  volume={73 3},
  pages={334-6}
}
Resistance to activated protein C (APC) is the most common risk factor for venous thromboembolism, a major cause of morbidity and mortality with an incidence of about 1/1,000 per year. The Arg 506 to Gln mutation in exon 10 of the coagulation factor V gene (factor V-Leiden) has been found to be responsible for over 90% of the APC resistance cases and is an autosomal dominant trait. Initial studies have suggested that this mutation is restricted to individuals of European Caucasian extraction… CONTINUE READING