Prevalence of the Factor V Leiden Mutation in Children and Neonates with Thromboembolic Disease. ▴ 917

@article{Hagstrom1996PrevalenceOT,
  title={Prevalence of the Factor V Leiden Mutation in Children and Neonates with Thromboembolic Disease. ▴ 917},
  author={J. Nathan Hagstrom and Johannes Walter and Rachel O. Bluebond-Langner and Catherine S. Manno and Katherine A High},
  journal={Pediatric Research},
  year={1996},
  volume={39},
  pages={155-155}
}
OBJECTIVE Resistance to activated protein C (APC) has been identified as a risk factor for thrombotic disease in adults. In over 90% of cases, the basis for the APC resistance is a mutation in the coagulation factor V gene (factor V Leiden) that renders the protein more resistant to inactivation by APC. We sought to determine the prevalence of the factor V Leiden (FVL) mutation in neonates and children who had experienced an arterial or venous thromboembolic event. STUDY DESIGN We… CONTINUE READING
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