Prevalence of polymorphisms with significant resistance to NS5A inhibitors in treatment-naive patients with hepatitis C virus genotypes 1a and 3a in Sweden.

@article{Lindstrm2015PrevalenceOP,
  title={Prevalence of polymorphisms with significant resistance to NS5A inhibitors in treatment-naive patients with hepatitis C virus genotypes 1a and 3a in Sweden.},
  author={Ida Lindstr{\"o}m and Midori Kjellin and Navaneethan Palanisamy and K{\aa}re Bondeson and Lars Wessl{\'e}n and Anders Lannerg{\aa}rd and Johan Lennerstrand},
  journal={Infectious diseases},
  year={2015},
  volume={47 8},
  pages={555-62}
}
BACKGROUND The future treatment of hepatitis C virus (HCV) infection will be combinations of direct-acting antivirals (DAAs) that not only target multiple viral targets, but are also effective against different HCV genotypes. Of the many drug targets in HCV, one promising target is the non-structural 5A protein (NS5A), against which inhibitors, namely daclatasvir, ledipasvir and ombitasvir, have shown potent efficacy. However, since HCV is known to have very high sequence diversity, development… CONTINUE READING
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