Prevalence of pfhrp2 and/or pfhrp3 Gene Deletion in Plasmodium falciparum Population in Eight Highly Endemic States in India

@inproceedings{Bharti2016PrevalenceOP,
  title={Prevalence of pfhrp2 and/or pfhrp3 Gene Deletion in Plasmodium falciparum Population in Eight Highly Endemic States in India},
  author={P. K. Bharti and Himanshu Singh Chandel and Amreen Ahmad and Sri Krishna and Venkatachalam Udhayakumar and Neeru Singh},
  booktitle={PloS one},
  year={2016}
}
BACKGROUND Plasmodium falciparum encoded histidine rich protein (HRP2) based malaria rapid diagnostic tests (RDTs) are used in India. Deletion of pfhrp2 and pfhrp3 genes contributes to false negative test results, and large numbers of such deletions have been reported from South America, highlighting the importance of surveillance to detect such deletions. METHODS This is the first prospective field study carried out at 16 sites located in eight endemic states of India to assess the… CONTINUE READING
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False-negative rapid diagnostic tests for malaria and deletion of the histidine-rich repeat region of the hrp2 gene.

The American journal of tropical medicine and hygiene • 2012
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