Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids

@article{Moore2005PrevalenceOO,
  title={Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids},
  author={R Andrew Moore and H. J. McQuay},
  journal={Arthritis Research & Therapy},
  year={2005},
  volume={7},
  pages={R1046 - R1051}
}
Adverse events of opioids may restrict their use in non-cancer pain. Analysis of the incidence of common adverse events in trials conducted in non-cancer pain has usually been limited to opioids used to treat severe pain according to the WHO three-step ladder. To examine the incidence of common adverse events of opioids in non-cancer pain, a systematic review and meta-analysis of information from randomised trials of all opioids in non-cancer pain was undertaken. Studies used were published… CONTINUE READING

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Dry mouth ( affecting 25% of patients ) , nausea ( 21% ) , and constipation ( 15% ) were the most common adverse events .
Dry mouth ( affecting 25% of patients ) , nausea ( 21% ) , and constipation ( 15% ) were the most common adverse events .
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