Prevalence of neurofascin-155 antibodies in patients with multiple sclerosis
@article{Stich2016PrevalenceON, title={Prevalence of neurofascin-155 antibodies in patients with multiple sclerosis}, author={Oliver Stich and S A Perera and Benjamin Berger and Sven Jarius and Brigitte Wildemann and A. Baumgartner and Sebastian Rauer}, journal={Journal of the Neurological Sciences}, year={2016}, volume={364}, pages={29-32} }
10 Citations
From PNS to CNS: characteristics of anti-neurofascin 186 neuropathy in 16 cases
- Biology, PsychologyNeurological Sciences
- 2021
It is worth noting that quite a few patients show CNS-impaired signs only, and cranial MRI is essential for the screening of CNS involvement, and CSF white blood cell counts were found significantly elevated in CNS-involved patients compared with patients of PNS group.
Anti-neurofascin autoantibody and demyelination
- Biology, MedicineNeurochemistry International
- 2018
A case with Neurofascin-155 IgG antibody-associated combined central and peripheral demyelination: Successfully treated with anti-CD20 monoclonal antibody
- Biology, MedicineClinical Neurology and Neurosurgery
- 2021
Autoantibodies in chronic inflammatory demyelinating polyradiculoneuropathy.
- Biology, MedicineCurrent opinion in neurology
- 2019
The discovery of autoantibodies against nodal and paranodal proteins has proven useful in clinical practice, has uncovered novel pathophysiological mechanisms, clinical phenotypes, therapeutic response and prognosis within the CIDP disease spectrum and has boosted the search for other clinically relevant autoantIBodies.
Role of B cells and antibodies in multiple sclerosis.
- Biology, MedicineMultiple sclerosis and related disorders
- 2019
Immunoadsorption and Plasma Exchange in Seropositive and Seronegative Immune-Mediated Neuropathies
- Medicine, BiologyJournal of clinical medicine
- 2020
Preliminary evidence suggests that GBS/CIDP patients without detectable IgG antibodies on routine diagnostic tests may nevertheless benefit from IA, and that an unbiased screening approach using myelinating co-cultures may assist in the detection of further autoantibodies which remain to be identified in such patients.
Nodes of Ranvier during development and repair in the CNS
- BiologyNature Reviews Neurology
- 2020
The organization and function of CNS nodes of Ranvier are described and how these nodes change in demyelination and remyelinating disorders is considered, highlighting the impact of these changes on neuronal physiology in health and disease as well as the associated therapeutic implications.
Formation and disruption of functional domains in myelinated CNS axons
- BiologyNeuroscience Research
- 2017
Molecular organization and function of vertebrate septate-like junctions.
- BiologyBiochimica et biophysica acta. Biomembranes
- 2020
Focal loss of the paranodal domain protein Neurofascin155 in the internal capsule impairs cortically induced muscle activity in vivo
- Biology, PsychologyMolecular brain
- 2020
Paranodal axoglial junctions are essential for rapid nerve conduction and the organization of axonal domains in myelinated axons. Neurofascin155 (Nfasc155) is a glial cell adhesion molecule that is…
References
SHOWING 1-10 OF 27 REFERENCES
Neurofascin as a target for autoantibodies in peripheral neuropathies
- Biology, MedicineNeurology
- 2012
Autoantibodies to NF are detected in a very small proportion of patients with AIDP and patients with CIDP, but may nevertheless be pathogenic in these cases.
Anti-neurofascin antibody in patients with combined central and peripheral demyelination
- Medicine, BiologyNeurology
- 2013
In anti-neurofascin antibody–positive CCPD patients, including those with a limited response to corticosteroids, IV immunoglobulin or plasma exchange alleviated the symptoms, recognition of this antibody may be important, because patients with CCPD who are antibody positive respond well to IV immunglobulinor plasma exchange.
Neurofascin IgG4 antibodies in CIDP associate with disabling tremor and poor response to IVIg
- Biology, MedicineNeurology
- 2014
This study provides Class IV evidence that autoantibodies to NF155 identify a CIDP subtype characterized by severe neuropathy, poor response to IVIg, and disabling tremor.
Elevated levels of antibody to myelin oligodendrocyte glycoprotein is not specific for patients with multiple sclerosis.
- Medicine, BiologyArchives of neurology
- 1999
The elevated presence of anti-MOG antibody is not specific for MS because a similar appearance was also demonstrated in patients with ONDs, and it is not clear whether this antibody is pathogenic in MS or, on the contrary, has a defensive role against further immune-mediated damage after myelin breakdown.
Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.
- Medicine, PsychologyBrain : a journal of neurology
- 2007
Data support an immunopathogenetic mechanism whereby B-cell follicles developing in the multiple sclerosis meninges exacerbate the detrimental effects of humoral immunity with a subsequent major impact on the integrity of the cortical structures.
Humoral autoimmunity in multiple sclerosis
- Biology, MedicineJournal of the Neurological Sciences
- 2011
Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis.
- Biology, PsychologyBrain : a journal of neurology
- 2006
The alterations in oligodendrocyte Nfasc155 expression that accompany inflammation and demyelination suggest an ongoing disruption to the axonal-oligodendROcyte complex within newly forming as well as established lesions in multiple sclerosis, resulting in destruction of the N fasc186+/Na+v nodal complex vital to successful fast neurotransmission in the CNS.
Nodal proteins are target antigens in Guillain‐Barré syndrome
- Biology, MedicineJournal of the peripheral nervous system : JPNS
- 2012
The prevalence of antibodies against nodal adhesion molecules in patients with Guillain‐Barré syndrome or chronic inflammatory demyelinating polyneuropathy (CIDP) is investigated and results suggest that antibody attack against nodding antigens participates in the etiology of GBS.
Axonal transection in the lesions of multiple sclerosis.
- Medicine, BiologyThe New England journal of medicine
- 1998
Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.