Prevalence of neurofascin-155 antibodies in patients with multiple sclerosis

@article{Stich2016PrevalenceON,
  title={Prevalence of neurofascin-155 antibodies in patients with multiple sclerosis},
  author={Oliver Stich and S A Perera and Benjamin Berger and Sven Jarius and Brigitte Wildemann and A. Baumgartner and Sebastian Rauer},
  journal={Journal of the Neurological Sciences},
  year={2016},
  volume={364},
  pages={29-32}
}
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12 Citations
Background Citations
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12 Citations

Antibodies against the flotillin-1/2 complex in patients with multiple sclerosis

TLDR
It is confirmed that antibodies targeting the Flotillin 1/2 complex are present in a subgroup of patients with MS, and further studies are needed to understand the clinical and pathological relevance of anti-FLOT1/2 autoantibodies in MS.

From PNS to CNS: characteristics of anti-neurofascin 186 neuropathy in 16 cases

TLDR
It is worth noting that quite a few patients show CNS-impaired signs only, and cranial MRI is essential for the screening of CNS involvement, and CSF white blood cell counts were found significantly elevated in CNS-involved patients compared with patients of PNS group.

Anti-neurofascin autoantibody and demyelination

A case with Neurofascin-155 IgG antibody-associated combined central and peripheral demyelination: Successfully treated with anti-CD20 monoclonal antibody

Anti-Neurofascin Antibodies Associated with White Matter Diseases of the Central Nervous System: A Red Flag or a Red Herring?

TLDR
Larger studies are needed to assess the relevance of ANFAs in demyelinating nervous system diseases, their impact on long-term clinical outcomes, and associated therapeutic implications.

Autoantibodies in chronic inflammatory demyelinating polyradiculoneuropathy.

TLDR
The discovery of autoantibodies against nodal and paranodal proteins has proven useful in clinical practice, has uncovered novel pathophysiological mechanisms, clinical phenotypes, therapeutic response and prognosis within the CIDP disease spectrum and has boosted the search for other clinically relevant autoantIBodies.

Role of B cells and antibodies in multiple sclerosis.

Immunoadsorption and Plasma Exchange in Seropositive and Seronegative Immune-Mediated Neuropathies

TLDR
Preliminary evidence suggests that GBS/CIDP patients without detectable IgG antibodies on routine diagnostic tests may nevertheless benefit from IA, and that an unbiased screening approach using myelinating co-cultures may assist in the detection of further autoantibodies which remain to be identified in such patients.

Focal loss of the paranodal domain protein Neurofascin155 in the internal capsule impairs cortically induced muscle activity in vivo

Paranodal axoglial junctions are essential for rapid nerve conduction and the organization of axonal domains in myelinated axons. Neurofascin155 (Nfasc155) is a glial cell adhesion molecule that is…

Nodes of Ranvier during development and repair in the CNS

TLDR
The organization and function of CNS nodes of Ranvier are described and how these nodes change in demyelination and remyelinating disorders is considered, highlighting the impact of these changes on neuronal physiology in health and disease as well as the associated therapeutic implications.

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TLDR
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TLDR
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