Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers.

@article{Hou2001PrevalenceON,
  title={Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers.},
  author={Jin-lin Hou and Z Wang and Jie Cheng and Yulong Lin and George Ka-Kit Lau and Jin Sun and Feng Zhou and Jenny Waters and Peter Karayiannis and Kangxian Luo},
  journal={Hepatology},
  year={2001},
  volume={34 5},
  pages={1027-34}
}
Previous studies have suggested that hepatitis B virus (HBV) variants may account for the presence of HBV DNA in hepatitis B surface antigen (HBsAg)-negative patients (occult HBV infection). However, it is not known how widespread these variants are and how they influence the course of liver disease. To determine the prevalence of variants within the major hydrophilic region (MHR) of HBsAg, we investigated 2,565 subjects, including subjects with chronic hepatitis, cryptogenic cirrhosis… CONTINUE READING
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