Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1-infected Italian patients with virologic failure.

@article{Balotta2000PrevalenceOM,
  title={Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1-infected Italian patients with virologic failure.},
  author={Claudia Balotta and Michela Violin and Laura Monno and Patrizia Bagnarelli and Chiara Riva and Gianalfredo Facchi and Aurelia Berlusconi and Manuela Lippi and Stefano Rusconi and Massimo Clementi and Massimo Galli and Gioacchino Angarano and Mauro Moroni},
  journal={Journal of acquired immune deficiency syndromes},
  year={2000},
  volume={24 3},
  pages={232-40}
}
We evaluated the prevalence of both Q151M and 6-bp insert at position 69 of RT region responsible for multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 variants in 177 patients who failed to respond to combination therapy. Patients had received protease inhibitors (PI) and/or nonnucleoside reverse transcriptase inhibitors (NNRTIs) after a long-term experience with nucleoside reverse transcriptase inhibitors (NRTIs) (including zidovudine monotherapy). Two of 177 patients (1.1%) showed… CONTINUE READING