Prevalence of microsatellite instability, inactivation of mismatch repair genes, p53 mutation, and human papillomavirus infection in Korean oral cancer patients.

@article{Shin2002PrevalenceOM,
  title={Prevalence of microsatellite instability, inactivation of mismatch repair genes, p53 mutation, and human papillomavirus infection in Korean oral cancer patients.},
  author={K S Shin and Kyung-hee Park and Hyun Jon Hong and Jin-man Kim and J Oh and P H Choung and Byung-Moo Min},
  journal={International journal of oncology},
  year={2002},
  volume={21 2},
  pages={297-302}
}
To determine the etiologic factors of human oral cancer, we examined the prevalence of microsatellite instability (MSI), the inactivation of mismatch repair (MMR) genes, p53 mutation, and human papillomavirus (HPV) infection (HPV-16, -18, and -33) in 86 Korean oral cancer specimens, including 76 squamous cell carcinomas and 10 salivary gland tumors. MSI was observed in 3 of the 76 squamous cell carcinomas (4%) and 2 of 10 salivary gland tumors (20%). As MSI is a hallmark of the inactivation of… CONTINUE READING