Prevalence of loss of expression of DNA mismatch repair proteins in primary epithelial ovarian tumors.

@article{Lu2012PrevalenceOL,
  title={Prevalence of loss of expression of DNA mismatch repair proteins in primary epithelial ovarian tumors.},
  author={Fang-I Lu and Cyril Blake Gilks and Anna-Marie Mulligan and Paul Ryan and Ghassan Allo and Keiyan Sy and Particia A Shaw and Aaron Pollett and Blaise Alexander Clarke},
  journal={International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists},
  year={2012},
  volume={31 6},
  pages={524-31}
}
Although different histologic subtypes of epithelial ovarian tumors have long been recognized, their molecular abnormalities have not been fully defined. We examined the prevalence of DNA mismatch repair (MMR) protein loss in these tumors. Tissue microarrays (TMA) of suspected ovarian carcinomas were stained for hMLH1, hMSH2, hMSH6, and hPMS2 and scored separately by 2 groups of investigators. Loss of staining (negative) or discrepant staining results on TMA were verified on whole-section… CONTINUE READING
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