Prevalence of important pathogens and the antimicrobial activity of parenteral drugs at numerous medical centers in the United States. II. Study of the intra- and interlaboratory dissemination of extended-spectrum beta-lactamase-producing Enterobacteriaceae.


The incidence of extended-spectrum beta-lactamases (ESBL)-producing Klebsiella pneumoniae and Escherichia coli has been increasing rapidly, and they are probably even more prevalent than is currently recognized because of difficulties in their detection by the clinical microbiology laboratory. In addition, several outbreaks associated with these… (More)