Prevalence of gyrA, gyrB, parC, and parE mutations in clinical isolates of Streptococcus pneumoniae with decreased susceptibilities to different fluoroquinolones and originating from Worldwide Surveillance Studies during the 1997-1998 respiratory season.

Abstract

From 8,419 worldwide clinical isolates of Streptococcus pneumoniae obtained during 1997-1998, 69 isolates with reduced susceptibility or resistance to fluoroquinolones (FQs) were molecularly characterized. For the isolates in this prevalence study, only parC (Ser-79-->Tyr) and gyrA (Ser-81-->Phe or Tyr) mutations, especially in combination, were found to… (More)

Topics

2 Figures and Tables

Cite this paper

@article{Jones2000PrevalenceOG, title={Prevalence of gyrA, gyrB, parC, and parE mutations in clinical isolates of Streptococcus pneumoniae with decreased susceptibilities to different fluoroquinolones and originating from Worldwide Surveillance Studies during the 1997-1998 respiratory season.}, author={M. E. Jones and Daniel F. Sahm and N. Martin and Simon Scheuring and Philipp Heisig and Clyde Thornsberry and Karl K{\"o}hrer and Friederike Schmitz}, journal={Antimicrobial agents and chemotherapy}, year={2000}, volume={44 2}, pages={462-6} }