Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain.

@article{Caldes2002PrevalenceOG,
  title={Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain.},
  author={Trinidad Caldes and Javier Godino and Miguel de la Hoya and Iciar Garcia Carbonero and Pedro P{\'e}rez Segura and Charis Eng and Manuel Benito and Eduardo Diaz-Rubio},
  journal={International journal of cancer},
  year={2002},
  volume={98 5},
  pages={774-9}
}
HNPCC is an autosomal dominantly inherited cancer-susceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract cancers. The underlying pathogenic mutation lies in 1 of the 5 known DNA MMR genes (MSH2, MLH1, PMS1, PMS2 and MSH6). We screened a total of 140 individuals from 56 Spanish families with suspected HNPCC for… CONTINUE READING

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