Prevalence of germline TP53 mutations in a prospective series of unselected patients with adrenocortical carcinoma.

@article{Raymond2013PrevalenceOG,
  title={Prevalence of germline TP53 mutations in a prospective series of unselected patients with adrenocortical carcinoma.},
  author={Victoria M Raymond and Tobias Else and Jessica N. Everett and Jessica M Long and Stephen B. Gruber and Gary D Hammer},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2013},
  volume={98 1},
  pages={E119-25}
}
PURPOSE Adrenocortical carcinoma (ACC) is a hallmark cancer in families with Li Fraumeni syndrome (LFS) caused by mutations in the TP53 gene. The prevalence of germline TP53 mutations in children diagnosed with ACC ranges from 50-97%. Although existing criteria advocate for TP53 testing in all patients with ACC regardless of age at diagnosis, the overall prevalence of germline mutations in patients diagnosed with ACC has not been well studied. PATIENTS AND METHODS A total of 114 patients with… CONTINUE READING

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