Prevalence of genetically defined tumor cells in CD7 as well as CD26 positive and negative circulating T-cell subsets in Sézary syndrome.

@article{Steinhoff2009PrevalenceOG,
  title={Prevalence of genetically defined tumor cells in CD7 as well as CD26 positive and negative circulating T-cell subsets in S{\'e}zary syndrome.},
  author={Matthias Steinhoff and Sebastian Sch{\"o}pp and Chalif Assaf and Marcus Muche and Marc Beyer and Wolfram Sterry and Ansgar Lukowsky},
  journal={Leukemia research},
  year={2009},
  volume={33 1},
  pages={88-99}
}
For diagnosis and monitoring of Sézary syndrome flow cytometric quantification of CD7- and CD26- T-cells is widely used. Because antigen loss is a characteristic but not disease-specific finding we investigated the significance of this approach. Therefore we analyzed the prevalence of tumor cells in FACS-sorted CD7+/- as well as CD26+/- circulating T-cells applying a clone-specific qualitative and quantitative T-cell receptor PCR. Tumor cells varied considerably in the CD7+ and CD7- cell subset… CONTINUE READING