Prevalence of genetic variants associated with cardiovascular disease risk and drug response in the Southern Indian population of Kerala

@inproceedings{Mahadevan2014PrevalenceOG,
  title={Prevalence of genetic variants associated with cardiovascular disease risk and drug response in the Southern Indian population of Kerala},
  author={Lakshmi Shree Mahadevan and Ancy Yesudas and P. K. Sajesh and S. Revu and Mirayala Gireesh Kumar and Devi Santhosh and Sam Santhosh and Jagathala Mahalingam Sashikumar and Velliyur Kanniappan Gopalakrishnan and Joji Boben and Changanamkandath Rajesh},
  booktitle={Indian journal of human genetics},
  year={2014}
}
BACKGROUND AND AIM This study reports the prevalence of five clinically significant variants associated with increased risk of cardiovascular disorders, and variable responses of individuals to commonly prescribed cardiovascular drugs in a South Indian population from the state of Kerala. MATERIALS AND METHODS Genomic DNA isolated from 100 out-patient samples from Kerala were sequenced to examine the frequency of clinically relevant polymorphisms in the genes MYBPC3 (cardiomyopathy), SLCO1B1… CONTINUE READING
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