Prevalence of feline leukaemia provirus DNA in feline lymphomas

@article{Weiss2010PrevalenceOF,
  title={Prevalence of feline leukaemia provirus DNA in feline lymphomas},
  author={Alexander Th. A. Weiss and Robert Klopfleisch and Achim D. Gruber},
  journal={Journal of Feline Medicine and Surgery},
  year={2010},
  volume={12},
  pages={929 - 935}
}
A significant drop in the prevalence of feline leukaemia virus (FeLV) antigenaemic cats and antigen-associated lymphomas has been observed after the introduction of FeLV vaccination and antigen-testing with removal of persistently antigenaemic cats. However, recent reports have indicated that regressively infected cats may contain FeLV provirus DNA and that lymphoma development may be associated with the presence of provirus alone. In the present study, we investigated the presence of FeLV… 
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Decreased expression of endogenous feline leukemia virus in cat lymphomas: a case control study
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There is a decreased expression of enFeLV genes in lymphomas versus control samples, which contradicts previous observations for the exFeLV and suggests that a persistent stimulation of host immune cells is not an appropriate mechanism responsible for malignant transformation caused by feline endogenous retroviruses.
Changes in prevalence of progressive feline leukaemia virus infection in cats with lymphoma in Germany
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There was a significant decrease in the percentage of lymphoma cases associated with progressive FeLV infection from the first (59 per cent) to the second observation period, and other aetiologies than progressiveFeLV infection must have a greater impact on cancerogenesis among affected cats with lymphoma to date.
The evolution of novel subgroups of feline leukaemia virus
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Results indicate that strains of FeLV-A possessing residues D83 and D91 in their envelope glycoprotein display increased rates of viral replication, mediated by an enhanced interaction with their cognate receptor, THTR1, and this represents a novel mechanism of endogenous retroviral restriction.
Viral causes of feline lymphoma: retroviruses and beyond.
  • J. Beatty
  • Biology, Medicine
    Veterinary journal
  • 2014
TLDR
This review will focus on the current understanding of FeLV-associated and FIV-associated lymphoma and consider whether yet more viral aetiologies could be waiting to be discovered.
Feline Lymphoma and a High Correlation with Feline Leukaemia Virus Infection in Brazil.
TLDR
The degree of association between lymphoma and FeLV infection in Brazil was higher than that found in other countries, demonstrating the need to prevent and control the factors associated with infection.
Molecular Diagnosis of Felis catus Gammaherpesvirus 1 (FcaGHV1) Infection in Cats of Known Retrovirus Status with and without Lymphoma
TLDR
A history of fighting or roaming was identified as a novel epidemiological risk factor for FcaGHV1 detection, lending support to intercat aggression as a potential route of transmission and Prospective investigation of Fca GHV1 DNA detection as a prognostic marker in feline lymphoma is warranted.
Rapid characterization of feline leukemia virus infective stages by a novel nested recombinase polymerase amplification (RPA) and reverse transcriptase-RPA
TLDR
FeLV diagnosis using nRPA and RT-RPA are rapid and easily established in low resource settings, benefiting FeLV prognosis, prevention, and control of both horizontal and vertical transmission.
Prevalence of feline leukaemia provirus DNA in feline lymphomas
TLDR
An error is identified in the listing of primers by Weiss et al1 while attempting to utilize the method for detection of FeLV proviral DNA by semi-nested PCR, and the primers do not perform as intended.
Role of Feline Immunodeficiency Virus in Lymphomagenesis--Going Alone or Colluding?
TLDR
The possible mechanisms involved in FIV lymphomagenesis are reviewed, including the possible involvement of coinfections, notably those with gamma-herpesviruses.
Role of Retroviruses in Feline Lymphoma
TLDR
Three retroviruses have been identified in domestic cats: Feline immunodeficiency virus, feline leukaemia virus and feline foamy virus, which was previously known as feline syncytium-forming virus (FeSFV), which has a globally widespread distribution but differ in their potential to cause disease.
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