Prevalence of extracranial venous narrowing on catheter venography in people with multiple sclerosis, their siblings, and unrelated healthy controls: a blinded, case-control study

@article{Traboulsee2014PrevalenceOE,
  title={Prevalence of extracranial venous narrowing on catheter venography in people with multiple sclerosis, their siblings, and unrelated healthy controls: a blinded, case-control study},
  author={Anthony L. Traboulsee and Katherine B Knox and Lindsay Machan and Yinshan Zhao and Irene M.L. Yee and Alexander Rauscher and Darren Klass and Peter Szkup and Rob Otani and David Kopriva and Shantilal Lala and David K.B. Li and Dessa A. Sadovnick},
  journal={The Lancet},
  year={2014},
  volume={383},
  pages={138-145}
}

Tables from this paper

Prevalence of Extracranial venous Narrowing on Magnetic Resonance Venography is Similar in People with Multiple Sclerosis, Their Siblings, and Unrelated Healthy Controls: A Blinded, Case-Control Study

Jugular Anomalies in Multiple Sclerosis Are Associated with Increased Collateral Venous Flow

TLDR
Compared with healthy controls, patients with multiple sclerosis exhibit reduced venous flow in the main extracerebral drainage vein (internal jugular vein), and flow inThe paraspinal venous collaterals is elevated in patients with MS and exacerbated by venous stenosis.

Four-dimensional flow magnetic resonance imaging and ultrasound assessment of cerebrospinal venous flow in multiple sclerosis patients and controls

  • E. SchraubenS. Kohn A. Field
  • Medicine, Psychology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2017
TLDR
Three complementary imaging modalities were used to investigate the chronic cerebrospinal venous insufficiency hypothesis in patients with multiple sclerosis and two age- and sex-matched control groups: healthy volunteers and patients with other neurological diseases.

Lack of correlation between extracranial venous abnormalities and multiple sclerosis: a quantitative MRI study.

TLDR
The hypothesis of the presence of extracranial venous abnormalities in MS, both in terms of stenosis or flow measures, is not suitable is confirmed, and quantitative MRI analysis seems to exclude that extrac Ranous venous alterations are related to the disease.

Ultrasonographic Evaluation of Cerebral Arterial and Venous Haemodynamics in Multiple Sclerosis: A Case-Control Study

TLDR
The quantitative evaluation of cerebral blood flow (CBF) and CVF and their postural dependency may be related to a dysfunction of autonomic nervous system that seems to characterize more disabled MS patients.

How to objectively assess jugular primary venous obstruction

TLDR
It has been demonstrated, from normal anatomy findings, how the jugular bulb diameter normally exceeds 50% of the minimum diameter of the internal jugular vein, clearly showing the reason why Traboulsee et al .

The role of magnetic resonance imaging in assessing venous vascular abnormalities in the head and neck: a demonstration of cerebrospinal venous insufficiency in a subset of multiple sclerosis patients

TLDR
Good agreement is shown that there is a high incidence of stenosis and structural venous abnormalities in the MS population and that this change results in reduced outflow of the IJVs and increased collateralization of venous return to the heart compared to healthy controls.

No association between variations in extracranial venous anatomy and clinical outcomes in multiple sclerosis patients over 5 years

TLDR
The presence of variations in extracranial venous anatomy does not influence clinical outcomes over the 5-year follow-up in MS patients, according to the International Society for Neurovascular Disease proposed consensus criteria.

No Association of Chronic Cerebrospinal Venous Insufficiency with Multiple Sclerosis

  • R. FoxC. Diaconu Esther SH Kim
  • Medicine, Psychology
    Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 2015
TLDR
Five venous characteristics were recommended to evaluate CCSVI: criterion 1 evaluates extracranial reflux in the internal jugular or vertebral veins in sitting and supine positions, and criterion 5 assesses reverted postural control of the main cerebral venous outflow pathway.
...

References

SHOWING 1-10 OF 32 REFERENCES

Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis

TLDR
CDMS is strongly associated with CCSVI, a scenario that has not previously been described, characterised by abnormal venous haemodynamics determined by extracranial multiple venous strictures of unknown origin.

Extracranial venous hemodynamics in multiple sclerosis

TLDR
The data argue against CCSVI as the underlying mechanism of MS, and potentially dangerous endovascular procedures, proposed as novel therapy for MS, should not be performed outside controlled clinical trials.

Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a meta-analysis

TLDR
A meta-analysis of studies that reported the frequency of chronic Cerebrospinal venous insufficiency among patients with and those without multiple sclerosis showed a positive association between chronic cerebrospINAL venousinsufficiency and multiple sclerosis, but poor reporting of the success of blinding and marked heterogeneity among the studies included in the review precluded definitive conclusions.

Chronic cerebrospinal venous insufficiency: masked multimodal imaging assessment

TLDR
The findings lend no support for altered venous outflow dynamics as common among MS patients, nor do they likely contribute to the disease process.

Value of MR Venography for Detection of Internal Jugular Vein Anomalies in Multiple Sclerosis: A Pilot Longitudinal Study

TLDR
Conventional MRV has limited value for assessing IJV anomalies for both diagnostic and posttreatment purposes in patients with MS diagnosed with CCSVI.

No association of abnormal cranial venous drainage with multiple sclerosis: a magnetic resonance venography and flow-quantification study

TLDR
Findings suggestive of anomalies of the cranial venous outflow anatomy were frequently observed in both MS patients and healthy controls, and it is likely that these findings reflect anatomical variants of venous drainage rather than clinically relevant venousOutflow obstructions.

Venous drainage in multiple sclerosis

TLDR
The ECCS data contradict the postulated 100% prevalence of CCSVI criteria in MS and argue against a causal relationship of venous narrowing and MS, favoring the rejection of the CCS VI hypothesis.

Venous and cerebrospinal fluid flow in multiple sclerosis: A case‐control study

TLDR
There is no evidence confirming the suggested vascular multiple sclerosis hypothesis, and there are no differences regarding internal jugular venous outflow, aqueductal cerebrospinal fluid flow, or the presence ofinternal jugular blood reflux.

Assessment of jugular endovascular malformations in chronic cerebrospinal venous insufficiency: colour-Doppler scanning and catheter venography compared with intravascular ultrasound

TLDR
CD sonography was proven to be important in the anatomical characterization of CCSVI, providing useful information for correct intravascular treatment and CV was significantly inferior to CD sonography and IVUS in detecting JEM.